A 50-Year-Old Woman Comes to the Office for a Preventive

A 50-year-old woman comes to the office for a preventive examination.  She feels well and has no ongoing symptoms.  Medical and family histories are unremarkable.  The patient does not use tobacco or alcohol.  Blood pressure is 132/76 mm Hg and pulse is 72/min.  BMI is 25 kg/m².  Physical examination is normal.  The patient is up to date on breast and cervical screening but has not undergone colon cancer screening.  She is referred for colonoscopy, during which a single colon polyp is discovered.  The polyp is removed and sent for histologic analysis.  Which of the following pathologic findings is associated with the greatest risk of malignant transformation in this patient?

A) 1-cm sessile hyperplastic polyp
B) 2-cm sessile lymphoid polyp
C) 2-cm tubular adenomatous polyp
D) 2-cm villous adenomatous polyp
E) 3-cm pedunculated hamartomatous polyp

Correct Answer:

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