A 35-Year-Old Man Comes to the Office for Evaluation of a Rash

A 35-year-old man comes to the office for evaluation of a rash on his elbows.  The patient has had this rash intermittently for several months, but lately, it has become more persistent and bothersome.  He has had mild associated itching but no pain and has tried a topical moisturizing lotion without relief.  The patient installs tile floors for a residential construction company.  He has no chronic medical conditions and takes no regular medications.  The patient does not use tobacco, alcohol, or illicit drugs.  Vitals signs are within normal limits.  The rash on his elbow is shown below, and a similar rash is present on the other elbow. Which of the following histologic changes would be most likely if this patient's skin lesion were biopsied?

A) Epidermal hyperplasia
B) Granulomatous inflammation
C) Intense eosinophilic infiltration
D) Squamous cell dysplasia
E) Thinning of the epidermis

Correct Answer:

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