A 56-Year-Old Man Is Brought to the Emergency Department with New-Onset

A 56-year-old man is brought to the emergency department with new-onset tonic-clonic seizures.  His past medical history is unremarkable.  The patient recently has had right-sided headaches and has taken acetaminophen with some relief.  MRI of the brain reveals several round lesions in the right temporal lobe.  After initial evaluation, a stereotactic biopsy of one of the lesions is performed.  The biopsy results show neoplastic tissue containing a mutation in the gene that encodes BRAF, a protein kinase.  The point mutation results in a valine → glutamic acid substitution at position 600 of the protein.  Which of the following is the most likely diagnosis?

A) Glioblastoma
B) Melanoma
C) Prostate cancer
D) Renal cell carcinoma
E) Small cell lung cancer

Correct Answer:

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