A 12-Year-Old Boy Is Brought to the Office Due to a Week

A 12-year-old boy is brought to the office due to a week of nonproductive cough and rash.  He has also had low-grade fevers, malaise, and headaches.  The patient has no prior medical conditions and is up to date with immunizations.  Lung examination reveals bilateral crackles and wheezes.  There is a diffuse rash on his torso and extremities as shown in the exhibit. 
Which of the following is the most likely cause of this patient's skin lesions?

A) Cytotoxic T-cell-mediated epithelial injury
B) Inflammatory reaction in subcutaneous fat
C) Keratinocyte hyperproliferation and parakeratosis
D) Subepidermal immunoglobulin A deposition
E) Vasoactive mediator release from mast cells

Correct Answer:

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