A 17-Year-Old Boy Collapses While Jogging and Dies Despite Resuscitation

A 17-year-old boy collapses while jogging and dies despite resuscitation efforts.  He has no medical history; however, his family history is significant for an uncle who died suddenly at age 20.  The boy is 185.4 cm (6 ft 1 in) tall and weighs 80 kg (176.4 lb) .  Autopsy reveals significant left ventricular hypertrophy predominantly affecting the interventricular septum.  There are no valvular abnormalities.  Assuming the boy died of an inherited condition, which of the following proteins was most likely affected by the relevant mutation?

A) Beta-myosin heavy chain
B) Dystrophin
C) Fibrillin-1
D) Membrane potassium channel
E) Transthyretin

Correct Answer:

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