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A 60-Year-Old Man Comes to the Office with a 6-Month

Question 438

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A 60-year-old man comes to the office with a 6-month history of exertional chest pain that remits with rest.  His other medical conditions include hypertension, diabetes mellitus, and hypercholesterolemia.  An exercise stress test is positive for inducible ischemia.  Cardiac catheterization shows 80% occlusion of the right coronary artery and 60% occlusion of the left coronary artery.  The first step in the pathogenesis of this patient's coronary artery disease most likely involved which of the following cell types?


A) Endothelial cells
B) Interstitial fibroblasts
C) Macrophages
D) Mast cells
E) Pericytes
F) Platelets
G) Smooth muscle cells

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