A 62-Year-Old Man Comes to the Office for the Evaluation

A 62-year-old man comes to the office for the evaluation of jaundice.  Medical history is significant for uncontrolled type 2 diabetes mellitus and morbid obesity.  He does not use tobacco, alcohol, or illicit drugs.  There is no family history of liver disease.  Vital signs are within normal limits.  BMI is 47 kg/m².  Mild scleral icterus is present.  Heart and lung sounds are normal.  The abdomen is nontender and nondistended.  Trace bilateral lower extremity edema is present.  Laboratory studies reveal elevated transaminases.  A liver biopsy is obtained, and trichrome staining shows the following: Which of the following cells is directly responsible for the histologic finding indicated by the arrow?

A) Cholangiocytes
B) Hepatocytes
C) Kupffer cells
D) Sinusoidal endothelial cells
E) Stellate (Ito) cells

Correct Answer:

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