A Pharmaceutical Researcher Develops a Novel Antibacterial Drug That Works

A pharmaceutical researcher develops a novel antibacterial drug that works by inhibiting exonuclease activity during DNA replication.  When actively dividing Escherichia coli is exposed to the drug, enzyme-mediated nucleotide removal in the 5' to 3' direction is impaired, leading to inhibition of bacterial growth.  Which of the following enzymes is the most likely target of this drug?

A) DNA polymerase I
B) DNA polymerase III
C) Gyrase
D) Helicase
E) Ligase
F) Primase

Correct Answer:

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