Pharmacologic Researchers Develop a Novel Alkylating Chemotherapeutic Agent Against Glioblastoma

Pharmacologic researchers develop a novel alkylating chemotherapeutic agent against glioblastoma multiforme.  They find that malignant cells with methylation of the promoter region for the O⁶-methylguanine-DNA methyltransferase (MGMT) gene are more susceptible to this drug than cells without methylation.  Which of the following is the most likely function of the protein encoded by the gene?

A) Induction of apoptosis
B) Reducing major histocompatibility complex expression
C) Repairing DNA damage
D) Upregulation of telomerase

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free