A Case-Control Study Was Conducted to Estimate the Association Between

A case-control study was conducted to estimate the association between simvastatin therapy and serum levels of fibrinogen in patients who underwent percutaneous coronary intervention.  Cases were identified as patients who underwent percutaneous coronary intervention and had high periprocedural levels of fibrinogen (>400 mg/dL) , and controls were identified as patients who underwent percutaneous coronary interventions but had normal levels of fibrinogen (200-400 mg/dL) .  History of simvastatin therapy use was assessed through chart review for every patient.  The number of patients corresponding to each classification criteria is given in the table below. Which of the following is the best statistical method to estimate the association between simvastatin use and high serum fibrinogen levels in this study?

A) Analysis of variance
B) Chi-square test
C) Correlation analysis
D) Meta-analysis
E) Two-sample t-test

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