A 34-Year-Old Man Develops Severe Chest and Abdominal Pain While

A 34-year-old man develops severe chest and abdominal pain while shopping in a mall.  Paramedics arrive and find him in severe distress.  Several minutes later, he suffers a cardiac arrest with pulseless electrical activity and cannot be resuscitated.  Postmortem examination reveals an internal hemorrhage as the cause of death.  Histochemical evaluation of the patient's tissues reveals a defect affecting a large extracellular glycoprotein.  This protein is normally found abundantly in large blood vessels, periosteum, and zonular fibers of the lens and functions to form microfibrils by surrounding elastin.  This patient most likely suffered from which of the following conditions?

A) Ehlers-Danlos syndrome
B) Homocystinuria
C) Marfan syndrome
D) Osteogenesis imperfecta
E) Polycystic kidney disease
F) Vitamin C deficiency

Correct Answer:

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