A 45-Year-Old Man Is Referred to an Endocrinologist for Newly

A 45-year-old man is referred to an endocrinologist for newly diagnosed diabetes mellitus.  A week ago, his primary care physician noted an elevated fasting serum glucose level.  The endocrinologist discusses the different treatment options available, including oral and injectable medications.  He recommends treatment with a medication that alters glucose metabolism within the liver by increasing the concentration of fructose 2,6-bisphosphate within hepatocytes.  Which of the following conversions will be inhibited by high intracellular concentrations of this metabolite?

A) Acetyl CoA → fatty acids
B) Alanine → glucose
C) Fructose-6-phosphate → fructose-1,6-bisphosphate
D) Glucose → glycogen
E) NAD⁺ → NADH

Correct Answer:

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