An Investigator Is Studying Weight Regulation Using Experimental Mouse Models

An investigator is studying weight regulation using experimental mouse models.  Knockout mice are created with a homozygous mutation in the gene coding for the leptin receptor.  This mutation prevents the receptor from binding leptin and initiating its normal signaling cascade.  The knockout mice are allowed to feed at will, and their body mass index (BMI) and serum leptin levels are measured and compared with control mice.  On the graph below, area C represents the normal relationship between BMI and leptin in a control mouse. Which of the following areas represents the expected relationship between BMI and serum leptin levels in a leptin receptor mutant mouse?

A) A
B) B
C) C
D) D
E) E

Correct Answer:

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