The Growth Factor Superchick Stimulates the Proliferation of Cultured Chicken

The growth factor Superchick stimulates the proliferation of cultured chicken cells.The receptor that binds Superchick is a receptor tyrosine kinase (RTK) , and many chicken tumor cell lines have mutations in the gene that encodes this receptor.Which of the following types of mutation would be expected to promote uncontrolled cell proliferation?

A) a mutation that prevents dimerization of the receptor
B) a mutation that destroys the kinase activity of the receptor
C) a mutation that inactivates the protein tyrosine phosphatase that normally removes the phosphates from tyrosines on the activated receptor
D) a mutation that prevents the binding of the normal extracellular signal to the receptor

Correct Answer:

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