Proteins Bind Selectively to Small-Molecule Targets Called Ligands

Proteins bind selectively to small-molecule targets called ligands.The selection of one ligand out of a mixture of possible ligands depends on the number of weak, noncovalent interactions in the protein's ligand-binding site.Where is the binding site typically located in the protein structure?

A) on the surface of the protein
B) inside a cavity on the protein surface
C) buried in the interior of the protein
D) forms on the surface of the protein in the presence of ligand

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