Canine Phosphofructokinase PFK) Deficiency Afflicts Springer Spaniels, Affecting an Estimated

Canine phosphofructokinase PFK) deficiency afflicts springer spaniels, affecting an estimated 10% of the breed. PFK is the glycolytic enzyme that phosphorylates fructose- 1- phosphate and catalyzes the committed step in glycolysis. Given its critical role in glycolysis, one implication of the genetic defect resulting in PFK deficiency in dogs is

A) elevated blood- glucose levels.
B) nothing. It would have no visible effect on the health of the animal.
C) exercise intolerance.
D) early embryonic mortality.

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