Exam 5: Genetic Linkage and Mapping in Eukaryotes

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Two genes, A and X, exhibit incomplete linkage. The frequency of each parental gamete (AX and ax)is 45%. What is the approximate frequency of the Ax gamete?

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When does recombination occur?

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In a two-point test-cross analysis, a dihybrid F1 fly is crossed to a __________.

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The specific array of alleles making up a set of linked genes on a single chromosome is called a ________.

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The syntenic genes A and Z are linked. A cross between two parents, AAZZ and aazz, produces F1 progeny with the AaZz genotype. What are the possible arrangements of alleles on the F1 progeny's chromosomes?

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Crossing over occurs frequently during meiosis. Can crossing over occur during mitosis? Explain why mitotic crossing over may or may not be possible.

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The products of meiosis yield the following results: PD = 1200 TT = 750 NPD = 50 What is the recombination frequency?

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Which type of crossover event produces no recombinant chromosomes?

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Alleles of linked genes usually segregate together during meiosis. When they don't, it is because ________ has occurred between them.

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Genetic linkage leads to the production of a significantly greater than expected number of gametes containing chromosomes with __________.

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What unit of physical distance between genes on a chromosome provides a convenient way to relate the recombination frequencies for linked genes with their positions and order along a chromosome?

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Intragenic recombination can be detected __________.

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Genetic linkage can be spotted by comparing the observed frequencies of ________ with the frequencies expected (assuming independent assortment).

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In fruit flies, red eyes (pr+_)are dominant to purple eyes (prpr)and normal wings (vg+_)are dominant to vestigial wings (vgvg). The genes are located on the same chromosome. A purebreeding red-eyed fly with vestigial wings was crossed with a pure-breeding purple-eyed fly with normal wings. All of the F1 progeny had a WT phenotype. Which of the following represents the arrangement of alleles on the F1's chromosome?

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If you are given a recombination frequency of 34% between genes X and Y and 27% between X and Z, can you predict the order of the three genes?

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If too little time has passed for crossing over to randomize haplotypes or if natural selection favors certain haplotypes, what would you expect to see?

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In most tests of genetic linkage, the number of double crossovers is less than the number expected due to what effect, which limits the number of crossovers that can occur in a short length of chromosome?

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A chromosome with a different combination of alleles than parental that is created by crossing over between homologous chromosomes is termed ________.

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Where does crossing over occur?

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5% recombination is equal to ________ map unit(s)(m.u.)or centimorgan(s)(cM)of distance between linked genes.

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