Exam 5: Psychopharmacology and New Drug Development

Tolerance may develop to some effects of a drug,but not to others.

Subjects in Phase 1 of clinical trials on humans during new drug development typically include __________.

The phenomenon of _________ occurs when repeated administration of a drug results in reduced response to that drug.

A __________ is a consequence of a behavior that increases the likelihood that it will occur in the future.

__________ means a state of equilibrium or balance.

If an individual learns to compensate for his or her drunkenness by walking more slowly,this would be an example of _________ tolerance.

A specified dose of a drug administered to a man and a woman on average will have greater effects on the woman.This is because of differences in __________.

The elderly are more sensitive to drug effects because their enzyme systems may be impaired,resulting in increased duration of drug action.

__________ tolerance is a type of functional tolerance that is measured within the course of action of a single dose or first few doses of a drug.

In drug studies,the generalizability from animals to humans is poor.

Which of the following are examples of conditioned stimuli associated with substance use?

__________ tolerance to a drug occurs when there is increased sensitivity to the effects of the drug with repeated use.

How long does the post-marketing testing of a new drug take?

When given __________,the usual disruption in behavior produced by introducing the punishment component in "conflict paradigm" experiments does not occur.

Cell adaptation theory assumes that a drug's action occurs on specific cells in the central nervous system.

In __________ tolerance,tolerance to one drug may extend to other closely related drugs.

What can be concluded from the results of the 1993 Concorde study?

_________ is an example of a drug that was approved too early,before potential side effects could adequately be explored.

Drug self-administration studies indicate that __________.

In the United States,the Drug Enforcement Administration sets the guidelines regulating new drug development.