Question 1

You are given a vial with 15 ml of 0.5% prilocaine to do an arm block. How many mg of prilocaine are you injecting?

Accepted Answer

A) 7.5 mg 
B) 15 mg 
C) 30 mg 
D) 50 mg 
E) 75 mg 
A) 7.5 mg 
B) 15 mg 
C) 30 mg 
D) 50 mg 
E) 75 mg E

Question 2

Which of the following drugs has an average half life of 50 hours?

Accepted Answer

A) Nortriptylline 
B) Digoxin 
C) Trimethoprim 
D) Valproic acid 
E) Lithium 
A) Nortriptylline 
B) Digoxin 
C) Trimethoprim 
D) Valproic acid 
E) Lithium B

Question 3

Which of the following is >90% bound to plasma proteins?

Accepted Answer

A) Atenolol 
B) Diazepam 
C) Gentamycin 
D) Lithium 
E) Theophylline 
A) Atenolol 
B) Diazepam 
C) Gentamycin 
D) Lithium 
E) Theophylline B

Question 4

Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by

Accepted Answer

A) Concomitant treatment with phenobarbital 
B) Use of these drugs by smokers 
C) Use of antihistamines by persons of Asian background 
D) A genetic predisposition to metabolise succinylcholine slowly 
E) Treatment of these patients with ketoconazole 
A) Concomitant treatment with phenobarbital 
B) Use of these drugs by smokers 
C) Use of antihistamines by persons of Asian background 
D) A genetic predisposition to metabolise succinylcholine slowly 
E) Treatment of these patients with ketoconazole

Question 5

Which of the following receptor - ligand pathway is correct?

Accepted Answer

A) Insulin - G protein receptor 
B) Mineralocorticoid - tyrosine kinase receptor 
C) Vitamin D - intracellular receptor 
D) Adrenaline - ligand gated channel receptor 
E) Platelet derived growth factor - cytokine receptor 
A) Insulin - G protein receptor 
B) Mineralocorticoid - tyrosine kinase receptor 
C) Vitamin D - intracellular receptor 
D) Adrenaline - ligand gated channel receptor 
E) Platelet derived growth factor - cytokine receptor

Question 6

Regarding first order kinetics - all of the following are true EXCEPT

Accepted Answer

A) First order kinetics means rate of reaction is proportional to concentration 
B) First order kinetics is more common than zero order kinetics 
C) First order kinetics apply to exponential processes 
D) First order kinetics generally apply to high plasma concentrations (>20 mg / 100 ml) of ethanol 
E) First order kinetics result in steady state concentrations after multiple dosing. 
A) First order kinetics means rate of reaction is proportional to concentration 
B) First order kinetics is more common than zero order kinetics 
C) First order kinetics apply to exponential processes 
D) First order kinetics generally apply to high plasma concentrations (>20 mg / 100 ml) of ethanol 
E) First order kinetics result in steady state concentrations after multiple dosing.

Question 7

Age associated changes in pharmacokinetics include

Accepted Answer

A) Reduction in creatinine clearance in 2/3 population 
B) Decreased body fat 
C) Increase body water 
D) A greater reduction in conjugation compared with oxidation 
E) A decreased absorption related to age alone 
A) Reduction in creatinine clearance in 2/3 population 
B) Decreased body fat 
C) Increase body water 
D) A greater reduction in conjugation compared with oxidation 
E) A decreased absorption related to age alone

Question 8

An example of drugs that undergo chemical antagonism is

Accepted Answer

A) Insulin - glucagon 
B) Protamine - heparin 
C) Prednisone - glipizide 
D) Morphine - naloxone 
E) Phenoxybenzamine - prazosin 
A) Insulin - glucagon 
B) Protamine - heparin 
C) Prednisone - glipizide 
D) Morphine - naloxone 
E) Phenoxybenzamine - prazosin

Question 9

Which of the following has the largest volume of distribution?

Accepted Answer

A) Digoxin 
B) Imipramine 
C) Lithium 
D) Chloroquine 
E) Trimethoprim 
A) Digoxin 
B) Imipramine 
C) Lithium 
D) Chloroquine 
E) Trimethoprim

Question 10

Regarding pharmacology principles

Accepted Answer

A) Diffusion is directly proportional to thickness and inversely proportional to surface area 
B) LD50 - 50% of the dose that kills most people 
C) Efficacy is the maximum response produced by a drug 
D) A partial agonist is always less potent than a full agonist 
E) EC50 = concentration of agonist that results in maximal response in 50% of patients 
A) Diffusion is directly proportional to thickness and inversely proportional to surface area 
B) LD50 - 50% of the dose that kills most people 
C) Efficacy is the maximum response produced by a drug 
D) A partial agonist is always less potent than a full agonist 
E) EC50 = concentration of agonist that results in maximal response in 50% of patients

Question 11

Regarding biotransformation

Accepted Answer

A) Phase one reactions always precede phase two reactions 
B) Skin is an organ involved in drug biotransformation 
C) Water conjugation is a phase one reaction 
D) CYP2D6 accounts for the majority of P450 activity 
E) Epoxidation is phase two biotransformation 
A) Phase one reactions always precede phase two reactions 
B) Skin is an organ involved in drug biotransformation 
C) Water conjugation is a phase one reaction 
D) CYP2D6 accounts for the majority of P450 activity 
E) Epoxidation is phase two biotransformation

Question 12

Which of the following drugs has a volume of distribution >2000 ?/70kg?

Accepted Answer

A) Aspirin 
B) Imipramine 
C) Digoxin 
D) Propranolol 
E) Chloroquine 
A) Aspirin 
B) Imipramine 
C) Digoxin 
D) Propranolol 
E) Chloroquine

Question 13

The metabolic pathway of detoxification that become increasingly important in paracetamol toxicity is

Accepted Answer

A) Conjugation with glucuronide 
B) Oxidation 
C) Reduction 
D) Methylation 
E) Cytochrome p450 dependent glutathione conjugation 
A) Conjugation with glucuronide 
B) Oxidation 
C) Reduction 
D) Methylation 
E) Cytochrome p450 dependent glutathione conjugation

Question 14

All of the following have 100% oral bioavailability EXCEPT

Accepted Answer

A) Valproic acid 
B) Trimethoprim 
C) Digoxin 
D) Diazepam 
E) Lithium 
A) Valproic acid 
B) Trimethoprim 
C) Digoxin 
D) Diazepam 
E) Lithium

Question 15

Which of the following has the shortest half life?

Accepted Answer

A) Theophylline 
B) Diazepam 
C) Aspirin 
D) Lithium 
E) Digoxin 
A) Theophylline 
B) Diazepam 
C) Aspirin 
D) Lithium 
E) Digoxin

Question 16

Which of the following statements is correct?

Accepted Answer

A) The half life is the time taken for a parameter to fall to 1/4 its original value 
B) Partial agonists act at receptor sites to cause maximal pharmacological effect at high doses 
C) Diazepam has a high extraction ratio and is thus subject to flow dependent elimination 
D) Morphine and pethidine have the same potency 
E) A patient with oedema will have an increased volume of distribution of tobramycin 
A) The half life is the time taken for a parameter to fall to 1/4 its original value 
B) Partial agonists act at receptor sites to cause maximal pharmacological effect at high doses 
C) Diazepam has a high extraction ratio and is thus subject to flow dependent elimination 
D) Morphine and pethidine have the same potency 
E) A patient with oedema will have an increased volume of distribution of tobramycin

Question 17

Drugs that enhance other drug metabolism include all of the following EXCEPT

Accepted Answer

A) Rifampicin 
B) Ketoconazole 
C) Phenobarbital 
D) Griseofulvin 
E) Phenytoin 
A) Rifampicin 
B) Ketoconazole 
C) Phenobarbital 
D) Griseofulvin 
E) Phenytoin

Question 18

All of the following drugs are >90% plasma protein bound EXCEPT

Accepted Answer

A) Diazepam 
B) Frusemide 
C) Fluoxetine 
D) Gentamicin 
E) Warfarin 
A) Diazepam 
B) Frusemide 
C) Fluoxetine 
D) Gentamicin 
E) Warfarin

Question 19

Which of the following is a phase one reaction?

Accepted Answer

A) Reduction 
B) Acetylation 
C) Glucuronidation 
D) Methylation 
E) Sulphate conjugation 
A) Reduction 
B) Acetylation 
C) Glucuronidation 
D) Methylation 
E) Sulphate conjugation

Question 20

Clearance of which drug involves capacity limited elimination?

Accepted Answer

A) Theophylline 
B) Gentamycin 
C) Digoxin 
D) Lithium 
E) Phenytoin 
A) Theophylline 
B) Gentamycin 
C) Digoxin 
D) Lithium 
E) Phenytoin

You are given a vial with 15 ml of 0.5% prilocaine to do an arm block. How many mg of prilocaine are you injecting?

Which of the following drugs has an average half life of 50 hours?

Which of the following is >90% bound to plasma proteins?

Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by

Which of the following receptor - ligand pathway is correct?

Regarding first order kinetics - all of the following are true EXCEPT

Age associated changes in pharmacokinetics include

An example of drugs that undergo chemical antagonism is

Which of the following has the largest volume of distribution?

Regarding pharmacology principles

Regarding biotransformation

Which of the following drugs has a volume of distribution >2000 ?/70kg?

The metabolic pathway of detoxification that become increasingly important in paracetamol toxicity is

All of the following have 100% oral bioavailability EXCEPT

Which of the following has the shortest half life?

Which of the following statements is correct?

Drugs that enhance other drug metabolism include all of the following EXCEPT

All of the following drugs are >90% plasma protein bound EXCEPT

Which of the following is a phase one reaction?

Clearance of which drug involves capacity limited elimination?

Drug Elimination, Biotransformation, Receptor Regulation, and Kinetics

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Exam 1: Pharmacokinetics and Drug Properties

You are given a vial with 15 ml of 0.5% prilocaine to do an arm block. How many mg of prilocaine are you injecting?

Which of the following drugs has an average half life of 50 hours?

Which of the following is >90% bound to plasma proteins?

Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by

Which of the following receptor - ligand pathway is correct?

Regarding first order kinetics - all of the following are true EXCEPT

Age associated changes in pharmacokinetics include

An example of drugs that undergo chemical antagonism is

Which of the following has the largest volume of distribution?

Regarding pharmacology principles

Regarding biotransformation

Which of the following drugs has a volume of distribution >2000 ?/70kg?

The metabolic pathway of detoxification that become increasingly important in paracetamol toxicity is

All of the following have 100% oral bioavailability EXCEPT

Which of the following has the shortest half life?

Which of the following statements is correct?

Drugs that enhance other drug metabolism include all of the following EXCEPT

All of the following drugs are >90% plasma protein bound EXCEPT

Which of the following is a phase one reaction?

Clearance of which drug involves capacity limited elimination?

Drug Elimination, Biotransformation, Receptor Regulation, and Kinetics

Filters