Question 1

_____________ is sulfhydryl moiety containing.

Accepted Answer

A) Captopril 
B) Enalapril 
C) Fosinopril 
D) Bepridil 
A) Captopril 
B) Enalapril 
C) Fosinopril 
D) Bepridil A

Question 2

The principal action common to all class I antiarrhythmic drugs is:

Accepted Answer

A) Na+ channel blockade 
B) K+ channel opening 
C) Depression of impulse conduction 
D) Prolongation of effective refractory period 
A) Na+ channel blockade 
B) K+ channel opening 
C) Depression of impulse conduction 
D) Prolongation of effective refractory period A

Question 3

Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate:

Accepted Answer

A) Coronary 
B) Cutaneous 
C) Renal 
D) Cranial 
A) Coronary 
B) Cutaneous 
C) Renal 
D) Cranial C

Question 4

Hydralazine is synthesized from

Accepted Answer

A) 2-formyl benzoic acid and Hydrazine 
B) Methacrylic acid 
C) 2-azidoethanol 
D) o-nitro toluene 
A) 2-formyl benzoic acid and Hydrazine 
B) Methacrylic acid 
C) 2-azidoethanol 
D) o-nitro toluene

Question 5

2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of

Accepted Answer

A) Flecainide 
B) Atenolol 
C) Verapamil 
D) Lignocaine 
A) Flecainide 
B) Atenolol 
C) Verapamil 
D) Lignocaine

Question 6

The antiarrhythmic drug which decreases both rate of depolarization (phase 0) as well as rate of repolarization (phase 3) of myocardial fibres is:

Accepted Answer

A) Lignocaine 
B) Propranolol 
C) Quinidine 
D) Verapamil 
A) Lignocaine 
B) Propranolol 
C) Quinidine 
D) Verapamil

Question 7

Losartan is

Accepted Answer

A) Renin release blocker 
B) ACE inhibitor 
C) Angiotension I blocker 
D) Angiotension II blocker 
A) Renin release blocker 
B) ACE inhibitor 
C) Angiotension I blocker 
D) Angiotension II blocker

Question 8

Given drug is

Accepted Answer

A) ? blocker 
B) ? blocker 
C) K+ channel blocker 
D) Ca++ channel blocker 
A) ? blocker 
B) ? blocker 
C) K+ channel blocker 
D) Ca++ channel blocker

Question 9

Angiotensin II causes rise in blood pressure by:

Accepted Answer

A) Direct vasoconstriction 
B) Releasing adrenaline from adrenal medulla 
C) Increasing central sympathetic tone 
D) All of the above 
A) Direct vasoconstriction 
B) Releasing adrenaline from adrenal medulla 
C) Increasing central sympathetic tone 
D) All of the above

Question 10

Organic nitrates relax vascular smooth muscle by:

Accepted Answer

A) Increasing intracellular cyclic GMP 
B) Increasing intracellular cyclic AMP 
C) Decreasing intracellular cyclic AMP 
D) Both 'A' and 'C' are correct 
A) Increasing intracellular cyclic GMP 
B) Increasing intracellular cyclic AMP 
C) Decreasing intracellular cyclic AMP 
D) Both 'A' and 'C' are correct

Question 11

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:

Accepted Answer

A) Increase in total coronary blood flow 
B) Redistribution of coronary blood flow 
C) Reduction of cardiac preload 
D) Reduction of cardiac afterload 
A) Increase in total coronary blood flow 
B) Redistribution of coronary blood flow 
C) Reduction of cardiac preload 
D) Reduction of cardiac afterload

Question 12

Nitrate tolerance is least likely to develop with the use of:

Accepted Answer

A) Sustained release oral glyceryl trinitrate 
B) Sublingual glyceryl trinitrate 
C) Transdermal glyceryl trinitrate 
D) Oral pentaerythritol tetranitrate 
A) Sustained release oral glyceryl trinitrate 
B) Sublingual glyceryl trinitrate 
C) Transdermal glyceryl trinitrate 
D) Oral pentaerythritol tetranitrate

Question 13

Identify high ceiling diuretic.

Accepted Answer

A) Chlorthiazide 
B) Furosemide 
C) Spironolactone 
D) Amiloride 
A) Chlorthiazide 
B) Furosemide 
C) Spironolactone 
D) Amiloride

Question 14

Phase II in cardiac action potential is

Accepted Answer

A) Fast depolarization 
B) Partial repolarization 
C) Plateau 
D) Repolarization 
A) Fast depolarization 
B) Partial repolarization 
C) Plateau 
D) Repolarization

Question 15

Digitalis slows the heart in congestive heart failure by:

Accepted Answer

A) Increasing vagal tone 
B) Decreasing sympathetic overactivity 
C) Direct depression of sinoatrial node 
D) All of the above 
A) Increasing vagal tone 
B) Decreasing sympathetic overactivity 
C) Direct depression of sinoatrial node 
D) All of the above

Question 16

1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol is IUPAC name of

Accepted Answer

A) Atenolol 
B) Metoprolol 
C) Captopril 
D) Hydralazine 
A) Atenolol 
B) Metoprolol 
C) Captopril 
D) Hydralazine

Question 17

Methyldopa is

Accepted Answer

A) Parasympathomimetic 
B) Parasympatholytic 
C) Sympathomimetic 
D) Sympatholytic 
A) Parasympathomimetic 
B) Parasympatholytic 
C) Sympathomimetic 
D) Sympatholytic

Question 18

In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at

Accepted Answer

A) C- 15 
B) C- 16 
C) C-17 
D) C -18 
A) C- 15 
B) C- 16 
C) C-17 
D) C -18

Question 19

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:

Accepted Answer

A) Glyceryl trinitrate 
B) Isosorbide dinitrate 
C) Isosorbide mononitrate 
D) Erythrityl tetranitrate 
A) Glyceryl trinitrate 
B) Isosorbide dinitrate 
C) Isosorbide mononitrate 
D) Erythrityl tetranitrate

Question 20

Given structure is of

Accepted Answer

A) Captopril 
B) Enalapril 
C) Fosinopril 
D) Bepridil 
A) Captopril 
B) Enalapril 
C) Fosinopril 
D) Bepridil

_____________ is sulfhydryl moiety containing.

The principal action common to all class I antiarrhythmic drugs is:

Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate:

Hydralazine is synthesized from

2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of

The antiarrhythmic drug which decreases both rate of depolarization (phase 0) as well as rate of repolarization (phase 3) of myocardial fibres is:

Losartan is

Given drug is

Angiotensin II causes rise in blood pressure by:

Organic nitrates relax vascular smooth muscle by:

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:

Nitrate tolerance is least likely to develop with the use of:

Identify high ceiling diuretic.

Phase II in cardiac action potential is

Digitalis slows the heart in congestive heart failure by:

1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol is IUPAC name of

Methyldopa is

In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:

Given structure is of

Cardiovascular Medications

Blood Pressure and Diuretics

Pharmacology and Drug Therapy

Chemical and Biological Aspects

Filters

Exam 1: Cardiovascular Drugs

_____________ is sulfhydryl moiety containing.

The principal action common to all class I antiarrhythmic drugs is:

Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate:

Hydralazine is synthesized from

2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of

The antiarrhythmic drug which decreases both rate of depolarization (phase 0) as well as rate of repolarization (phase 3) of myocardial fibres is:

Losartan is

Given drug is

Angiotensin II causes rise in blood pressure by:

Organic nitrates relax vascular smooth muscle by:

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:

Nitrate tolerance is least likely to develop with the use of:

Identify high ceiling diuretic.

Phase II in cardiac action potential is

Digitalis slows the heart in congestive heart failure by:

1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol is IUPAC name of

Methyldopa is

In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:

Given structure is of

Cardiovascular Medications

Blood Pressure and Diuretics

Pharmacology and Drug Therapy

Chemical and Biological Aspects

Filters