Exam 11: Gene Mutation, Dna Repair, and Homologous Recombination

Which pathway is affected by an inherited mutation in the ATM gene?

A strain of E. coli is unable to use the UV repair pathway because of an apparent absence of DNA helicase activity. Which UV repair gene is likely mutated in this strain?

Which mechanism can be used to repair UV damage in Drosophila but not in humans?

Which enzyme is required to mobilize transposons of any type?

When a DNA mismatch is detected in E.coli, what mechanism allows the cell to determine which was more likely to be the original nucleotide?

DNA glycosylase inhibitors are used to study which DNA repair mechanism?

A second- site mutation that compensates for the mutation in one gene by mutating a second gene and restoring the wild- type phenotype is also known as a ___________mutation.

You have developed a new drug and have been asked to test the drug's mutagenicity before putting it on the market. Which test could you use to determine your compound's mutagenic potential?

A mutant DNA polymerase that increases the frequency of strand slippage would increase the frequency of which type of mutation?

What type of mutation commonly affects CpG islands, altering promoter regions of mammalian genes?

Which of the following is able to cause a change in a reading frame?

If one Holliday junction region is resolved by an NS cut and the other by an EW cut, the resulting chromosomes___________ .