Sickle-Cell Anemia Is Caused By

Sickle-cell anemia is caused by:

A) a decreased production of α chains of hemoglobin.
B) a substitution of a glutamic acid residue for a phenylalanine residue at the β6 position.
C) the loss of the heme group because the proximal His is oxidized.
D) a substitution of a valine residue for a glutamic acid residue at the β6 position.
E) a substitution of glutamic acid residue for histidine at the C terminal of the α chain.

Correct Answer:

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