The Adaptive Immune System Uses Multiple Strategies to Generate Diversity

The adaptive immune system uses multiple strategies to generate diversity in our ability to mount responses to a wide array of infectious microorganisms. These strategies include the generation of diverse repertoires of B-cell and T-cell antigen receptors, as well as polymorphism of MHC genes. The polymorphism of MHC genes differs from the diversity of lymphocyte antigen receptors in that:

A) It involves DNA rearrangements at multiple gene segments in the MHC locus.
B) It requires different enzymes than the RAG1/RAG2 recombinase required for antigen receptor rearrangements.
C) It results in a diverse repertoire of clonally distributed receptors on dendritic cells, rather than on lymphocytes.
D) It creates diversity between individuals in the population rather than within a single individual.
E) It does not contribute to the transplant rejection responses that occur after organ transplantation between unrelated individuals.

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