Studies Using Mouse Models of Allergic Asthma Have Provided Information

Studies using mouse models of allergic asthma have provided information about the cell types and soluble mediators that contribute to this disease. One common experimental model uses airway exposure to protease allergens, such as papain from papaya or the house dust mite allergen. Interestingly, papain is able to induce allergic lung inflammation even in RAG-deficient mice. In this system, the type 2 cytokines, IL-5, IL-9, and IL-13, are likely coming from:

A) Airway epithelial cells
B) ILC2 cells
C) Eosinophils
D) T_H2 cells
E) Macrophages

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