Why Has the One Gene - One Polypeptide Hypothesis Had

Why has the One Gene - One Polypeptide hypothesis had to be modified?

A) It was totally wrong.
B) Genes can be spliced differently to generate a variety of related polypeptides.
C) Enzymes sometimes consist of more than one polypeptide,each of which is coded for by its own gene.
D) Enzymes actually code for genes.
E) Polypeptides code for genes.

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