A Molecule Such as 2,4-Dinitrophenol Works to Uncouple the Proton

A molecule such as 2,4-dinitrophenol works to uncouple the proton gradient. Which of the following is true about 2,4-DNP?

A) 2,4-DNP is protonated in the matrix and deprotonated in the intermembrane space.
B) The presence of an uncoupler results in an increase in the activity of the TCA cycle and electron transport
C) 2,4-DNP is a very ineffective uncoupler because its hydrophobic structure prevents it from effectively crossing lipid bilayer membranes.
D) 2,4-DNP has been used as a very effective diet aid for the past 70 years
E) none of the above are correct

Correct Answer:

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