CREB Is a Transcription Factor That Regulates Gene Expression

CREB is a transcription factor that regulates gene expression. It binds to DNA and activates promoters of genes involved in addictive behaviors in alcoholism. Researchers compared CREB levels in the brains of a strain of rats called P rats and wild-type rats. When P rats consumed alcohol,

A) the total levels of CREB increased.
B) the total levels of CREB decreased.
C) the total levels of CREB remained the same.
D) levels of phosphorylated CREB increased.
E) levels of phosphorylated CREB decreased.

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