Why Do Some Signals ("First Messengers") Trigger "Second Messengers" to Activate

Why do some signals ("first messengers") trigger "second messengers" to activate target cells?

A) The first messenger requires activation by ATP.
B) The first messenger is not water soluble.
C) The first messenger binds to many types of cells.
D) The first messenger cannot cross the plasma membrane.
E) There are no receptors for the first messenger.

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