The Transition State of an Enzyme and Substrate Reaction

The transition state of an enzyme and substrate reaction

A) must always bind the enzyme active site with lower energy than the products.
B) is stabilized by enhancing the reverse reaction of E + S→ES.
C) is composed of true covalent bonds which decrease its energy.
D) is stabilized due to the specificity of the active site for the substrate.
E) is stabilized by decreasing the effective concentration.

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