Which Is True About an Operator Constitutive (O^c)mutation

Which is true about an operator constitutive (O^c) mutation?

A) An O^c mutation on the chromosome can affect the expression of structural genes on a plasmid.
B) The O^c mutation prevents the expression of a diffusible product that regulates the lac operon.
C) An F' I+P+ O^c Z-Y+A-/I+P+O+Z+Y+A+ merozygote expresses the enzymes of the lac operon constitutively.
D) The O? mutations act only in cis.
E) An F' I+P+ O^c Z+Y+A+/I+P+O+Z-Y-A- merozygote is inducible for the three enzymes of the lac operon.

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