Which of the Following Best Explains Why an Enzyme Hasn't $\Delta$

Which of the following best explains why an enzyme hasn't evolved to catalyze the following reaction as the first step of glycolysis?
glucose + P_i -> glucose-6-phosphate
I.The use of ATP is required for this step to serve as a regulatory control point.
II.The use of ATP is important because it helps keep its concentration low.Otherwise the high [ATP] would slow glycolysis too much through feedback inhibition.
III.The large positive $\Delta$ G˚' of this reaction would need to be overcome by an exceedingly high [P_i].
IV.Inorganic phosphate cannot be specifically placed on the carbon in the 6^th position.

A) I, III
B) I, II
C) II, IV
D) I only
E) III only

Correct Answer:

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