Which of the Following Explains Why IgM Activates Complement So

Which of the following explains why IgM activates complement so effectively?

A) IgM is the principal isotype in the blood
B) Pentameric IgM has five constant regions available to interact with C1
C) IgM is made in the innate immune response and does not require previous exposure to antigen
D) IgM is transported across mucosal epithelium, where antigens are often first encountered by the host
E) IgM binds with high affinity to mast cells in the connective tissue and is strategically located beneath skin and mucosal surfaces

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