The Bcl-2 Gene Product in Its Normal Form Can Be

The Bcl-2 gene product in its normal form can be activated to prevent cells from undergoing apoptosis (programmed cell death)in specific circumstances.It is a carefully regulated gene,being "turned on" only under specific circumstances.A null mutation in Bcl-2 leads to excessive cell loss.Some Bcl-2 mutation can cause a "gain of function" in which the protein is active all the time.
a.In the terms used in this chapter,what would the normal version be called?
b.What would the gain-of-function mutation be called?
c.How would you expect the gain-of-function mutation to be involved in cancer?

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