When Constructing a YAC, Why Must a Large Amount of Random

When constructing a YAC, why must a large amount of random DNA be included?

A) The random DNA base pairs with DNA in the natural chromosomes of a cell.
B) YACs that are too small do not segregate properly during mitosis and the random DNA is used as filler.
C) The random DNA functions as telomeres.
D) The random DNA contains origins of replication needed for maintenance of the YAC.
E) The random DNA allows YACs to be used in both eukaryotic and prokaryotic cells.

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