How Do Extrapyramidal Side Effects Occur from Antipsychotic Medications If

How do extrapyramidal side effects occur from antipsychotic medications if dopamine neurons are overactivated in schizophrenia?

A) After antipsychotics bind to D₂ receptors in the limbic system, most drug molecules are left for blocking receptors in the basal ganglia.
B) Antipsychotics have a stronger affinity for dopamine receptors in the basal ganglia.
C) Mesolimbic neurons are overactivated in schizophrenia, but nigrostriatal neurons are not.
D) Inhibition of glutamate neurons in turn causes an inhibition of nigrostriatal neurons.

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