Tom Has a Condition in Which the Endothelial Lining of His

Tom has a condition in which the endothelial lining of his blood vessels cannot secrete prostacyclin (PGI₂) . How will this affect his blood?

A) Because prostacyclin is a clotting factor that encourages formation of platelet plugs, bleeding will not be slowed.
B) Prostacyclin is involved in the activation of prothrombin, so the process of clotting will not be complete.
C) Prostacyclin is a clot-dissolving enzyme, so clots will not be broken down and Tom will be at risk for an embolism or thrombosis.
D) Because prostacyclin prevents platelets from sticking to the inside of healthy blood vessels, Tom will experience clotting and general narrowing of the blood vessels.

Correct Answer:

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