Autosomal Dominant Inheritance for a Mutation Can Usually Be Ruled

Autosomal dominant inheritance for a mutation can usually be ruled out when which of the following is observed in a family?

A) The disease skips a generation
B) An affected child is born to unaffected parents
C) Transmission from father to son
D) The phenotype varies between affecteds in the family
E) The parents of the proband are consanguineous

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