A Patient Who Is Positive for the Human Immunodeficiency Virus

A patient who is positive for the human immunodeficiency virus (HIV) is diagnosed with a Cryptococcus neoformans infection.The attending resident prescribed Griseofulvin;however,the patient's condition did not seem to improve.Which one of the following statements explains this discrepancy?

A) The dose should be increased to penetrate the blood-brain barrier.
B) Nystatin,which would have been more effective,should have been prescribed.
C) Griseofulvin is not effective against C.neoformans;therefore the therapy should be changed.
D) Potassium iodide is the therapy of choice,not griseofulvin.

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