Traditional Therapy in APL Includes Pharmacological Concentration of Retinoic Acid

Traditional therapy in APL includes pharmacological concentration of retinoic acid (ATRA) and chemotherapy. What is the function of the chemotherapy component in this treatment protocol?

A) Induces maturation of the promyelocytes to mature granulocytes
B) Binds with the target PML/RARA gene and represses gene transcription
C) Eradicates the leukemic stem cells
D) Induces cytolysis of the malignant promyelocytes

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