Why Are Bone Changes and Deformities Common Findings in β-Thalassemias

Why are bone changes and deformities common findings in β-thalassemias?

A) The globin chain synthesis is increased.
B) The impaired globin chain synthesis causes erythroid hypoplasia.
C) The impaired globin chain synthesis causes increased erythropoiesis resulting in bone marrow expansion.
D) The impaired globin chain synthesis causes impaired oxygen delivery to the bone tissue, which causes bone deformities.

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