The TATA Sequence Is Found Approximately 25 Nucleotides Upstream from the Start

The TATA sequence is found approximately 25 nucleotides upstream from the start site of transcription. This most probably relates to which of the following?

A) its involvement with binding the transcription factor that helps place polymerase II in the correct location
B) its direct binding of polymerase II
C) the ability of this sequence to bind to the start site
D) the supercoiling of the DNA near the start site
E) the 3-D shape of a DNA molecule

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