Rank the Following 1-Base Point Mutations (From Most Likely to Least

Rank the following 1-base point mutations (from most likely to least likely) with respect to their likelihood of affecting the structure of the corresponding polypeptide: 1. insertion mutation deep within an intron
2) substitution mutation at the 3rd position of an exonic codon
3) substitution mutation at the 2nd position of an exonic codon
4) deletion mutation within the first exon of the gene

A) 1, 2, 3, 4
B) 4, 3, 2, 1
C) 2, 1, 4, 3
D) 3, 1, 4, 2
E) 2, 3, 1, 4

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