A Patient Who Is Having a Sickle Cell Crisis Asks

A patient who is having a sickle cell crisis asks the nurse why the sickling causes such pain. The nurse explains that the pain of sickling is caused by

A) spasms of the blood cells as they change shape.
B) deposition of sickled red cells in the bone marrow.
C) tissue hypoxia caused by small blood vessel occlusion.
D) infectious processes in organs affected by the sickling.

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