You Are Caring for a Child with Acute Lymphoblastic Leukemia

You are caring for a child with acute lymphoblastic leukemia. She has been genotyped and is homozygous for a TPMT polymorphism, producing very little of the enzymeneeded for this drug's metabolism. How would you expect this to affect dosing of the drug 6-mercaptopurine?

A) This child should receive only a small fraction of the standard dose.
B) This child should receive the drug intravenously rather than orally.
C) This child should receive higher doses than the standard dose.
D) This child should receive the standard dose.

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