What Makes a Frameshift Mutational Event More Serious Than a Point

What makes a frameshift mutational event more serious than a point mutational event?

A) Frameshift mutations occur primarily in germline cells, and point mutations occur only in somatic cells.
B) Frameshift mutations result in the deletion or addition of whole chromosomes (aneuploidy) , and point mutations are undetectable at the chromosome level.
C) The rate of frameshift mutations increases with aging because DNA repair mechanisms decline, whereas the rate of point mutations is unchanged with age.
D) When the mutations occur in expressed genes, frameshift mutations always result in disruption of the gene function, whereas a point mutation can be silent.

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