In Eukaryotic Cells, When a Protein Is to Be Translocated

In eukaryotic cells, when a protein is to be translocated to the endoplasmic reticulum, what must occur for complete translation to occur?

A) the N-terminus binds SRP which delivers the ribosome and growing peptide to the ER
B) the N-terminus binds SRP which is then partially cleaved by a signal peptidase
C) the ribosome must be translocated into the ER prior to initiation of translation
D) the ribosome must be bound to the ER before translation begins
E) a chaperone protein embedded in the ER membrane binds the N-terminus

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