The Hydrodynamic Radius May Complicate the Planned Elution of a Protein

The hydrodynamic radius may complicate the planned elution of a protein of a particular MW in that

A) a protein with spherical shape may elute later than expected from a column packed with 25-50 size beads
B) a protein with a prolate shape may elute later than expected from a column packed with 25-50 size beads
C) a protein with a prolate shape may elute earlier than expected from a column packed with 25-50 size beads
D) a protein with oblate shape may elute earlier than expected from a column packed with 1200 size beads
E) Both A and B

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