A Patient Is Taking 40 Mg PO of Simvastatin with Her

A patient is taking 40 mg PO of simvastatin with her evening meal. She comes to you to ask about what she read on the Internet about adverse effects, saying that for the last 2-3 weeks, her legs felt like they were cramping. Which of the following tests would you recommend?

A) Liver function tests
B) A CBC (complete blood count) and a full Comp Metabolic (chemistries) test
C) Total simvastatin urine concentrations
D) Creatine phosphokinase (CPK) , the MM isoenzyme.

Correct Answer:

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