Which Hypothesis Was Developed After It Was Shown That the Effects

Which hypothesis was developed after it was shown that the effects of high doses of ketamine are similar to symptoms of schizophrenia?

A) A major factor in schizophrenia is hypoactivity of the glutamatergic system, particularly NMDA receptor signaling.
B) A major factor in schizophrenia is 5-HT_2A receptor down-regulation.
C) A major factor in schizophrenia is hypoactivity of the serotonergic system due to 5-HT inhibition.
D) A major factor in schizophrenia is decreased dopaminergic transmission in the prefrontal cortex.

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