Which Statement About Glutamate and DA in Regard to Symptoms

Which statement about glutamate and DA in regard to symptoms associated with schizophrenia is true?

A) Overabundance of glutamate at the NMDA receptor may be a precursor to DA dysfunction and may explain increases in mesolimbic DA and decreases in PFC function.
B) Insufficient glutamate at the NMDA receptor may be a precursor to DA dysfunction and may explain increases in mesolimbic DA and decreases in PFC function.
C) NMDA receptors have indirect excitatory effects on of midbrain mesolimbic
DA neurons that project to limbic regions.
D) Schizophrenic symptoms are due to increased DA function in mesocortical neurons along with reduced DA function in mesolimbic dopaminergic neurons.

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